Dermal care is rising interest world widely. Research on dermatology focuses on anti-aging, skin moisturizing, atopy, skin regeneration and skin whitening. Graduation theses and published scientific journals from during the past 5 years regarding dermatological diseases were reviewed; We found 1,137 graduation theses and 137 scientific journals related to anti-aging. For skin-moisturizing, we found 1,060 graduation theses and 241 scientific journals. For atopic dermatitis, 156 graduation theses were most relevant among 3,453 graduation theses and 51 scientific journals were relevant among 1,006 journals. For skin-regeneration 413 graduation theses were found. In this case, most of what we needed were about keratinocyte regeneration (44 graduation theses and 23 scientific journals). Among all the herbal medicines that are related to dermatology, we chose 8 different herbs which are mostly stated (Glycyrrhizae Radix, Angelicae Gigantis Radix, Houttuyniae Herba, Cnidii Rhizoma, Scutellariae Radix, Forsythiae Fructus, Sophorae Radix, Gardeniae Fructus). In studies of herbal medicine, Glycyrrhizae Radix, Cnidii Rhizoma, Scutellariae Radix, Forsythiae Fructus are included in Chungsangbangpong-tang. Chungsangbang- pong-tang has an effect on skin-regeneration, skin-lightening and skin-moisturizing. Glycyrrhizae Radix and Cnidii Rhizoma are also included in Palmulgunja-tang. Allergy contact dermatitis is treated with Palmulgunja-tang. Angelicae Gigantis Radix is one of the most popular herbal medicine used in Asian countries. Studies on the effect of Angelicae Gigantis Radix have applied for anti-hyperglycemic, neuroprotective, anti-inflammatory, and antioxidant effects. Sophorae Radix is included in Samjasambaek-tang which is used to treat allergic dermatitis. In this study, For these 8 different herbal medicines, we used three different extract solvents as water, 50% EtOH, and 100% EtOH extract. We proceeded DPPH, total phenolic content, nitric oxide (NO) inhibition in RAW264.7
cells, and UVB irradiation assay in human keratino HaCaT cells. As a result, in the case of DPPH radical scavenging
activity, of total polyphenols content, of inhibiting NO production in RAW264.7 cells, inhibiting cytotoxicity by UVB irradiation in HaCaT human keratinocytes, 50% EtOH extract was the best. These results suggest that it is most appropriate to use 50% EtOH solvent in the manufacture of new materials to improve skin diseases through extraction of 8 types of herbal medicines in the future. Based on the results of this study, it is considered that further studies, such as mechanisms in skin cells and setting of indicator components, will be needed.
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